Generic Name: fluocinolone, hydroquinone, and tretinoin topical (FLOO oh SIN oh lone, HYE droe KWIN one, TRET in oin)
Brand Names: Tri-Luma
What is fluocinolone, hydroquinone, and tretinoin topical?
Fluocinolone is a steroid. It reduces inflammation or swelling.
Hydroquinone topical is a skin bleaching agent.
Tretinoin topical is a form of vitamin A. It helps the skin to renew itself more quickly.
The combination of fluocinolone, hydroquinone, and tretinoin topical is used to treat melasma (dark skin patches) of the face.
Fluocinolone, hydroquinone, and tretinoin topical may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about fluocinolone, hydroquinone, and tretinoin topical?
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). This medication can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun. Avoid getting this medication in your mouth, eyes, or nose, and avoid applying it to your lips or in the creases of your nose. If it does get into any of these areas, rinse with water. Do not use the medication on sunburned, windburned, dry, chapped, irritated, or broken skin. Wait until these areas have healed.
Your skin may be more sensitive to weather extremes such as cold and wind. Protect your skin with clothing and use a moisturizing cream or lotion as needed.
Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.
What should I discuss with my healthcare provider before using fluocinolone, hydroquinone, and tretinoin topical?
Before using this medication, tell your doctor if you are allergic to sulfites or if you have asthma.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
The pill form of tretinoin is known to cause birth defects. Although your skin does not absorb as much tretinoin as if you were taking the medication by mouth, it may be best not to use fluocinolone, hydroquinone, and tretinoin topical if you are pregnant. Talk to your doctor first.
Fluocinolone, hydroquinone, and tretinoin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I use fluocinolone, hydroquinone, and tretinoin topical?
Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.
Fluocinolone, hydroquinone, and tretinoin topical is usually applied nightly, at least 30 minutes before bedtime. Follow your doctor's instructions.
Using use this medication in larger amounts or applying it more often than prescribed will not make it work any faster, and it may increase side effects.
Gently wash your face with a mild cleanser before applying this medication. Rinse and pat dry the skin.
Use only your fingers to apply the medication. Put a pea-sized amount of cream on your fingertip. Apply a thin layer to the discolored skin spots and spread it out to about one-half inch of the skin around the discolored spot. Rub in gently and completely.
Avoid getting this medication in your mouth, eyes, or nose, and avoid applying it to your lips or in the creases of your nose. If it does get into any of these areas, rinse with water. Do not use the medication on sunburned, windburned, dry, chapped, irritated, or broken skin. Wait until these areas have healed. Do not use fluocinolone, hydroquinone, and tretinoin topical on skin that is sunburned, windburned, dry, chapped, or irritated. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have healed before using fluocinolone, hydroquinone, and tretinoin topical.
Do not apply skin moisturizers or cosmetics after applying this medication. Ask your doctor about using skin moisturizers or cosmetics during the day.
Fluocinolone, hydroquinone, and tretinoin topical should be used as part of a complete skin care program that includes avoiding sunlight, using an effective sunscreen (minimum SPF of 30), and wearing protective clothing.
Store fluocinolone, hydroquinone, and tretinoin topical at room temperature away from moisture and heat.
What happens if I miss a dose?
Use the missed dose as soon as you remember, or wait until the next night to apply the medication. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
An overdose of fluocinolone, hydroquinone, and tretinoin topical applied to the skin is not likely to cause life-threatening symptoms.
What should I avoid while using fluocinolone, hydroquinone, and tretinoin topical?
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). This medication can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.
Your skin may be more sensitive to weather extremes such as cold and wind. Protect your skin with clothing and use a moisturizing cream or lotion as needed.
Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.
Fluocinolone, hydroquinone, and tretinoin topical side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor if you have any of these serious side effects:
darkening of the treated skin;
severe skin irritation, blistering, oozing, scaling, or crusting;
severe burning or swelling of the skin; or
irritation of your eyes, nose, or mouth.
Less serious side effects may include:
mild redness, burning, stinging, tingling, itching, swelling, dryness, or peeling of your skin;
rash;
acne;
skin bumps or blisters; or
more noticeable red lines or blood vessels showing through your skin.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Fluocinolone, hydroquinone, and tretinoin topical Dosing Information
Usual Adult Dose for Melasma:
Apply thin film to hyperpigmented areas and 1/2 inch of surrounding skin once daily at night, at least 30 minutes before bedtime.
Wash face and neck and pat skin dry before applying.
Duration: Treatment may continue intermittently for up to 6 months of cumulative drug exposure.
What other drugs will affect fluocinolone, hydroquinone, and tretinoin topical?
Before using this medication, tell your doctor if you also use other medications that can make you more sensitive to sunlight, including:
a diuretic (water pill);
a tetracycline antibiotic, including minocycline (Dynacin, Minocin, Vectrin), doxycycline (Doryx, Monodox, Vibramycin, Vibra-Tabs), demeclocycline (Declomycin), and others;
a fluoroquinolone antibiotic such as ciprofloxacin (Cipro), levofloxacin (Levaquin), and others;
a sulfa drug such as Bactrim, Septra, Cotrim, and others;
phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), or trifluperazine (Stelazine); or
birth control pills or hormone replacement therapy.
This list is not complete and there may be other drugs that can interact with fluocinolone, hydroquinone, and tretinoin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
More fluocinolone, hydroquinone, and tretinoin topical resources
- Fluocinolone, hydroquinone, and tretinoin topical Side Effects (in more detail)
- Fluocinolone, hydroquinone, and tretinoin topical Dosage
- Fluocinolone, hydroquinone, and tretinoin topical Use in Pregnancy & Breastfeeding
- Fluocinolone, hydroquinone, and tretinoin topical Drug Interactions
- Fluocinolone, hydroquinone, and tretinoin topical Support Group
- 7 Reviews for Fluocinolone, hydroquinone, and tretinoin - Add your own review/rating
Compare fluocinolone, hydroquinone, and tretinoin topical with other medications
- Melasma
Where can I get more information?
- Your pharmacist can provide more information about fluocinolone, hydroquinone, and tretinoin topical.
See also: fluocinolone, hydroquinone, and tretinoin side effects (in more detail)
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